V5 region in the HIV-1 envelope glycoprotein determines viral sensitivity to the broadly neutralizing monoclonal antibody VRC01

Abstract

Background VRC01, a broadly neutralizing monoclonal antibody (bnmAbs), is capable of neutralizing a diverse array of HIV-1 isolates through recognition of the loop D and the V5 regions within the CD4 binding site on envelope glycoprotein gp120. Nonetheless, resistant strains have been identified. Here, we examined two closely related envelope clones derived at a single time point from a CRF08_BC infected patient which displayed an over 20-fold difference in VRC01 neutralization sensitivity.

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